The SF3B6 Polyclonal Antibody (CAB13097) is a valuable tool for researchers studying SF3B6, a key protein involved in RNA splicing and gene expression regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to SF3B6, this antibody enables precise detection and analysis of the protein in a variety of cell types, making it an essential component for investigations in molecular biology and gene expression studies.SF3B6 is a crucial component of the spliceosome complex, responsible for removing introns from pre-mRNA molecules during the process of splicing. Dysregulation of this splicing machinery has been linked to various diseases, including cancer, genetic disorders, and neurodegenerative diseases.
Therefore, studying SF3B6 and its role in RNA splicing is essential for understanding the molecular mechanisms underlying these conditions and developing potential therapeutic interventions.By using the SF3B6 Polyclonal Antibody (CAB13097), researchers can gain valuable insights into the function and regulation of SF3B6, ultimately contributing to advancements in the fields of molecular biology, genetics, and disease research. Its high specificity and sensitivity make it a reliable tool for investigations into RNA splicing mechanisms and gene expression control, paving the way for new discoveries and innovations in the field.
Product Name:
SF3B6 Rabbit Polyclonal Antibody
SKU:
CAB13097
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human SF3B6 (NP_057131.1).
This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site.
Purification Method:
Affinity purification
Gene ID:
51639
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SF3B6 Rabbit pAb (CAB13097) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
