SF3B3/SAP130 Rabbit Monoclonal Antibody (CAB9624)
- SKU:
- CAB9624
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | SF3B3/SAP130 Rabbit Monoclonal Antibody |
SKU: | CAB9624 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1101-1217 of human SF3B3/SAP130 (Q15393). |
Sequence: | VLSL QKTT LIPG GSES LVYT TLSG GIGI LVPF TSHE DHDF FQHV EMHL RSEH PPLC GRDH LSFR SYYF PVKN VIDG DLCE QFNS MEPN KQKN VSEE LDRT PPEV SKKL EDIR TRYA F |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | RSE1; SAP130; SF3b130; STAF130; SF3B3/SAP130 |
Positive Sample: | Hep G2,Mouse testis,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 136kDa |
Observed MW: | 130-136kDa |
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
Purification Method: | Affinity purification |
Gene ID: | 23450 |
Clone Number: | ARC1667 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |