SF3B3/SAP130 Rabbit Polyclonal Antibody (CAB6146)
- SKU:
- CAB6146
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | SF3B3/SAP130 Rabbit Polyclonal Antibody |
SKU: | CAB6146 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 948-1217 of human SF3B3/SAP130 (NP_036558.3). |
Sequence: | VPAA IAPF QGRV LIGV GKLL RVYD LGKK KLLR KCEN KHIA NYIS GIQT IGHR VIVS DVQE SFIW VRYK RNEN QLII FADD TYPR WVTT ASLL DYDT VAGA DKFG NICV VRLP PNTN DEVD EDPT GNKA LWDR GLLN GASQ KAEV IMNY HVGE TVLS LQKT TLIP GGSE SLVY TTLS GGIG ILVP FTSH EDHD FFQH VEMH LRSE HPPL CGRD HLSF RSYY FPVK NVID GDLC EQFN SMEP NKQK NVSE ELDR TPPE VSKK LEDI RTRY AF |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | RSE1; SAP130; SF3b130; STAF130; SF3B3/SAP130 |
Positive Sample: | Mouse ovary,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 136kDa |
Observed MW: | 136kDa |
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
Purification Method: | Affinity purification |
Gene ID: | 23450 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |