SF3B1 Rabbit Polyclonal Antibody (CAB15801)
- SKU:
- CAB15801
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | SF3B1 Rabbit Polyclonal Antibody |
SKU: | CAB15801 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-144 of human SF3B1 (NP_001005526.1). |
Sequence: | MAKI AKTH EDIE AQIR EIQG KKAA LDEA QGVG LDST GYYD QEIY GGSD SRFA GYVT SIAA TELE DDDD DYSS STSL LGQK KPGY HAPV ALLN DIPQ STEQ YDPF AEHR PPKI ADRE DEYK KHRR TMII SPER LDPF ADGF YSAA |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | MDS; PRP10; Hsh155; PRPF10; SAP155; SF3b155; SF3B1 |
Positive Sample: | U-87MG,Jurkat,HeLa,NIH/3T3,Mouse brain,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus speckle. |
Calculated MW: | 146kDa |
Observed MW: | 160kDa |
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 23451 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |