The SF3A3 Polyclonal Antibody (CAB4465) is a valuable tool for researchers studying SF3A3, a key component of the splicing factor 3 subcomplex involved in mRNA splicing. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blotting applications. By targeting the SF3A3 protein, this antibody allows for the detection and analysis of SF3A3 in various cell types, making it ideal for studies in molecular biology and gene expression regulation.SF3A3 plays a crucial role in the splicing process, ensuring the accurate removal of introns from pre-mRNA molecules.
Dysregulation of splicing factors like SF3A3 has been linked to a variety of diseases, including cancer and neurodegenerative disorders. By investigating the function of SF3A3, researchers can gain insight into the mechanisms underlying these conditions and potentially identify new therapeutic targets.Overall, the SF3A3 Polyclonal Antibody is a valuable resource for scientists investigating the role of SF3A3 in gene expression and disease pathology. Its high specificity and reliable performance make it a trusted tool for advancing our understanding of mRNA splicing and its implications for human health.
Product Name:
SF3A3 Rabbit Polyclonal Antibody
SKU:
CAB4465
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 292-501 of human SF3A3 (NP_006793.1).
This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
10946
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SF3A3 Rabbit pAb (CAB4465) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
