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SF-1 Polyclonal Antibody

SKU:
CAB24536
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€129 - €359
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Description

SF-1 Polyclonal Antibody (CAB24536)

The SF-1 Polyclonal Antibody is a key tool for researchers studying SF-1, a nuclear receptor protein involved in regulating gene expression and development of the endocrine system. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to SF-1, this antibody allows for precise detection and analysis of this important protein in various cell types, making it essential for studies in endocrinology and reproductive biology.SF-1, also known as steroidogenic factor 1, plays a crucial role in the development and function of hormone-producing glands such as the adrenal and gonads.

Dysregulation of SF-1 has been linked to disorders of sexual development, as well as adrenal and reproductive diseases. By understanding the function and regulation of SF-1, researchers can gain insights into the underlying mechanisms of these conditions and potentially develop targeted therapies. The SF-1 Polyclonal Antibody is a valuable tool for advancing our knowledge in this important area of research.

Product Name:SF-1 Polyclonal Antibody
Product Code:CAB24536
Reactivity:Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:Rat brain
Cellular Location:Nucleus

The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 218-461 of human SF-1 (NP_004950.2).
Sequence:SGGPN VPELI LQLLQ LEPDE DQVRA RILGC LQEPT KSRPD QPAAF GLLCR MADQT FISIV DWARR CMVFK ELEVA DQMTL LQNCW SELLV FDHIY RQVQH GKEGS ILLVT GQEVE LTTVA TQAGS LLHSL VLRAQ ELVLQ LLALQ LDRQE FVCLK FIILF SLDLK FLNNH ILVKD AQEKA NAALL DYTLC HYPHC GDKFQ QLLLC LVEVR ALSMQ AKEYL YHKHL GNEMP RNNLL IEMLQ AKQT
Synonyms:NR5A1, AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3, hSF-1, SRXX4, steroidogenic factor 1
Calculated MW:51kDa
Observed MW:50kDa

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