The SEZ6L Polyclonal Antibody (PAC020451) is a valuable tool for researchers studying SEZ6L, a cell surface protein associated with synaptic function and neurodevelopmental disorders. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in various applications, including Western blotting.SEZ6L, also known as seizure-related 6 homolog-like protein, is involved in synaptic transmission and has been linked to conditions like epilepsy and autism spectrum disorders. By targeting the SEZ6L protein, researchers can investigate its role in neurodevelopment and potentially develop new therapeutic approaches for these disorders.
The SEZ6L Polyclonal Antibody enables the detection and analysis of SEZ6L expression in different cell types, making it a valuable tool for studying neurological diseases and understanding the molecular mechanisms underlying synaptic function. Its specificity and reliability make it an essential component of research projects aimed at unraveling the complexities of neurodevelopmental disorders.
Antibody Name:
SEZ6L Antibody (PACO20451)
Antibody SKU:
PACO20451
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human SEZ6L
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20451(SEZ6L Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20451(SEZ6L Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
SEZ6L (seizure related 6 homolog-like) is a 1,024 amino acid, single-pass type I membrane protein that localizes to the endoplasmic reticulum. Widely expressed, SEZ6L is a candidate tumor suppressor gene and may contribute to specialized endoplasmic reticulum functions in neurons. SEZ6L contains three CUB domains and five sushi (CCP/SCR) domains, which may be involved in protein-protein interactions and signal transduction. The gene encoding SEZ6L is located on human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia.
Synonyms:
seizure related 6 homolog (mouse)-like
UniProt Protein Function:
SEZ6L: May contribute to specialized endoplasmic reticulum functions in neurons. Belongs to the SEZ6 family. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 22q12.1Cellular Component: endoplasmic reticulum membrane; cell soma; integral to membraneBiological Process: synapse maturation; adult locomotory behavior; cerebellar Purkinje cell layer development
