The SETD8 Polyclonal Antibody (CAB7305) is a valuable tool for researchers studying the SETD8 protein, an important epigenetic regulator involved in cell cycle progression and gene expression. Raised in rabbits, this antibody is highly specific to human SETD8 samples and has been validated for use in Western blot applications.SETD8, also known as PR-Set7 or KMT5A, is a histone methyltransferase that plays a crucial role in maintaining chromatin structure and gene transcription. Dysregulation of SETD8 has been linked to various diseases, including cancer and developmental disorders, making it a key target for therapeutic research.
By detecting and analyzing SETD8 protein levels in various cell types, this antibody enables researchers to gain insights into its function and potential as a therapeutic target. Its high reactivity and specificity make it an ideal tool for studies in epigenetics, cancer biology, and drug discovery. Unlock the potential of SETD8 research with the SETD8 Polyclonal Antibody (CAB7305).
Product Name:
KMT5A/SETD8 Rabbit Polyclonal Antibody
SKU:
CAB7305
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 73-352 of human KMT5A/KMT5A/SETD8 (NP_065115.3).
The protein encoded by this gene is a protein-lysine N-methyltransferase that can monomethylate Lys-20 of histone H4 to effect transcriptional repression of some genes. The encoded protein is required for cell proliferation and plays a role in chromatin condensation.
Purification Method:
Affinity purification
Gene ID:
387893
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KMT5A/KMT5A/SETD8 antibody (CAB7305) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
