The SETD8 Polyclonal Antibody (CAB5256) is a valuable tool for researchers studying the SETD8 protein, a histone methyltransferase involved in various cellular processes such as DNA replication and cell cycle regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in Western blotting and immunohistochemistry applications.SETD8 is known to play a critical role in gene expression regulation and chromatin organization, making it a key player in epigenetic mechanisms that influence cellular function and development.
Dysregulation of SETD8 has been linked to several diseases, including cancer and developmental disorders, emphasizing the importance of studying this protein in various research settings.By utilizing the SETD8 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of SETD8, ultimately advancing our understanding of its role in health and disease. This antibody's reliability and performance make it an essential tool for studies exploring epigenetic modifications and their impact on cellular physiology.
Product Name:
KMT5A/SETD8 Rabbit Polyclonal Antibody
SKU:
CAB5256
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-393 of human KMT5A/KMT5A/SETD8 (Q9NQR1).
The protein encoded by this gene is a protein-lysine N-methyltransferase that can monomethylate Lys-20 of histone H4 to effect transcriptional repression of some genes. The encoded protein is required for cell proliferation and plays a role in chromatin condensation.
Purification Method:
Affinity purification
Gene ID:
387893
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using (CAB5256) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
