The SET1A Polyclonal Antibody (CAB18231) is a valuable tool for researchers studying the histone methyltransferase SET1A, an enzyme involved in gene regulation and chromatin remodeling. This rabbit polyclonal antibody is highly specific to SET1A and has been validated for use in Western blot applications, allowing for the detection and analysis of SET1A protein levels in various cell types.SET1A plays a critical role in controlling gene expression by methylating histone proteins, ultimately affecting the packaging of DNA and gene transcription. Dysregulation of SET1A has been linked to various diseases, including cancer and developmental disorders.
Therefore, understanding the function and regulation of SET1A is essential for unraveling its role in gene expression and disease progression.By using the SET1A Polyclonal Antibody (CAB18231), researchers can further explore the mechanisms underlying SET1A-mediated gene regulation and its implications in various biological processes. This antibody provides a valuable tool for investigating the function of SET1A and its potential as a target for therapeutic interventions in diseases associated with epigenetic dysregulation.
The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily.
Purification Method:
Affinity purification
Gene ID:
9739
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SET1A Rabbit pAb (CAB18231) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 5min.
