The SET Polyclonal Antibody (CAB12513) is a valuable tool for researchers studying the SET protein, a key player in the regulation of gene expression and cell growth. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in applications such as Western blot and immunohistochemistry.The SET protein, also known as I2PP2A, plays a crucial role in a variety of cellular processes, including chromatin remodeling, DNA repair, and apoptosis. Dysregulation of SET has been linked to various diseases, including cancer, Alzheimer's, and cardiovascular disorders.
By targeting the SET protein, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially identify novel therapeutic targets.With its high reactivity and specificity, the SET Polyclonal Antibody (CAB12513) is a valuable tool for researchers investigating the functions and dysregulation of the SET protein in various disease contexts. Its versatility and reliability make it an essential component of studies in molecular biology, cancer research, and drug development.
Product Name:
SET/TAF1 Rabbit Polyclonal Antibody
SKU:
CAB12513
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 146-277 of human SET/TAF1 (NP_003002.2).
The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6418
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SET/TAF1 antibody (CAB12513) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
