The SET Polyclonal Antibody (CAB12502) is a valuable tool for researchers studying the SET protein, a key player in chromatin regulation and gene expression. This antibody, raised in rabbits, has a high reactivity with human, mouse, and rat samples, and is validated for use in Western blot and immunohistochemistry applications. By targeting the SET protein, this antibody allows for the detection and analysis of SET levels in various cell types, making it essential for investigating the role of SET in a wide range of cellular processes.The SET protein, also known as I2PP2A, is involved in diverse biological functions, including DNA repair, cell cycle regulation, and apoptosis.
Dysregulation of SET has been linked to various diseases, including cancer, neurological disorders, and cardiovascular diseases. By studying the function of SET, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for their treatment.Overall, the SET Polyclonal Antibody (CAB12502) is a versatile tool for researchers interested in unraveling the complex functions of the SET protein and its implications in human health and disease. Its high specificity and sensitivity make it an indispensable resource for studies in molecular biology, cancer research, and beyond.
Product Name:
SET/TAF1 Rabbit Polyclonal Antibody
SKU:
CAB12502
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 146-277 of human SET/TAF1 (NP_003002.2).
The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6418
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using SET/TAF1 Rabbit pAb (CAB12502) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
