The Sestrin-3 Polyclonal Antibody (CAB5164) is a powerful tool for research involving Sestrin-3, a protein known for its role in regulating cellular metabolism and oxidative stress response. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By specifically binding to the Sestrin-3 protein, this antibody enables the detection and analysis of Sestrin-3 in various cell types, making it an essential tool for studies in the fields of metabolism, aging, and oxidative stress.Sestrin-3 is a key player in cellular pathways that control energy balance and response to cellular stressors, making it a promising target for research on metabolic disorders, aging-related diseases, and oxidative stress-induced conditions.
Understanding the function of Sestrin-3 is crucial for developing potential therapies that target these pathways in the context of metabolic diseases, neurodegenerative disorders, and age-related conditions. The Sestrin-3 Polyclonal Antibody (CAB5164) provides researchers with a valuable tool to further explore the role of Sestrin-3 in health and disease.
Product Name:
SESN3 Rabbit Polyclonal Antibody
SKU:
CAB5164
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human SESN3 (NP_653266.2).
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
143686
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SESN3 antibody (CAB5164) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
