sestrin 1 Rabbit Monoclonal Antibody (CAB19787)
- SKU:
- CAB19787
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PA26
- SEST1
Frequently bought together:
Description
Product Name: | sestrin 1 Rabbit Monoclonal Antibody |
SKU: | CAB19787 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human sestrin 1 (Q9Y6P5). |
Sequence: | KTQH YLLQ MDGP LPLH YRHY IGIM AAAR HQCS YLVN LHVN DFLH VGGD PKWL NGLE NAPQ KLQN LGEL NKVL AHRP WLIT KEHI EGLL KAEE HSWS LAEL V |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | PA26; SEST1; sestrin 1 |
Positive Sample: | HepG2,PC-3 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytosol, Fibrillar center, Nucleoplasm, Nucleus |
Calculated MW: | 57kDa |
Observed MW: | 66kDa |
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method: | Affinity purification |
Gene ID: | 27244 |
Clone Number: | ARC2313 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |