SERPINI1 Rabbit Polyclonal Antibody (CAB15703)
- SKU:
- CAB15703
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | SERPINI1 Rabbit Polyclonal Antibody |
SKU: | CAB15703 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 181-410 of human SERPINI1 (NP_005016.1). |
Sequence: | INAV YFKG NWKS QFRP ENTR TFSF TKDD ESEV QIPM MYQQ GEFY YGEF SDGS NEAG GIYQ VLEI PYEG DEIS MMLV LSRQ EVPL ATLE PLVK AQLV EEWA NSVK KQKV EVYL PRFT VEQE IDLK DVLK ALGI TEIF IKDA NLTG LSDN KEIF LSKA IHKS FLEV NEEG SEAA AVSG MIAI SRMA VLYP QVIV DHPF FFLI RNRR TGTI LFMG RVMH PETM NTSG HDFE EL |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 |
Synonyms: | PI12; HNS-S1; HNS-S2; neuroserpin; SERPINI1 |
Positive Sample: | Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 46kDa |
Observed MW: | 46kDa |
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Purification Method: | Affinity purification |
Gene ID: | 5274 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |