The SERPINA1 Polyclonal Antibody (CAB15703) is a research tool designed for investigating SERPINA1, a serine protease inhibitor that plays a crucial role in regulating proteolytic enzyme activity. This antibody, produced in rabbits, boasts high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SERPINA1 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential tool for studies in molecular biology and disease research.SERPINA1, also known as alpha-1 antitrypsin, is a key player in maintaining protease-antiprotease balance in the body, particularly in regulating inflammation and tissue damage.
Dysregulation of SERPINA1 has been linked to various diseases, including liver disease, lung disorders, and inflammatory conditions. Investigating the function of SERPINA1 is critical for understanding its role in disease pathogenesis and developing therapeutic strategies targeting this protein.Overall, the SERPINA1 Polyclonal Antibody (CAB15703) offers researchers a reliable tool for studying the function and expression patterns of SERPINA1 in physiological and pathological conditions, ultimately contributing to advancements in biomedical research and clinical interventions.
Product Name:
SERPINI1 Rabbit Polyclonal Antibody
SKU:
CAB15703
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 181-410 of human SERPINI1 (NP_005016.1).
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Purification Method:
Affinity purification
Gene ID:
5274
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SERPINI1 Rabbit pAb (CAB15703) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
