The SERPINH1 Polyclonal Antibody (CAB13474) is a valuable tool for researchers interested in studying the function of SERPINH1, a protein involved in the regulation of collagen folding and extracellular matrix organization. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.SERPINH1, also known as heat shock protein 47 (HSP47), plays a crucial role in collagen biosynthesis by assisting in the proper folding and stabilization of collagen triple helices. Dysregulation of SERPINH1 has been implicated in various pathological conditions, including fibrosis, connective tissue disorders, and cancer.
By targeting SERPINH1, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic strategies.This SERPINH1 Polyclonal Antibody provides researchers with a reliable tool for detecting and quantifying SERPINH1 expression in a variety of cell types and tissues. Its high specificity and sensitivity make it an ideal choice for studies focused on understanding the role of SERPINH1 in health and disease. By utilizing this antibody, researchers can further elucidate the functions of SERPINH1 and its potential as a therapeutic target in various pathological conditions.
Product Name:
HSP47/SERPINH1 Polyclonal Antibody
SKU:
CAB13474
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 139-418 of human HSP47/HSP47/SERPINH1 (NP_001226.2).
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
Purification Method:
Affinity purification
Gene ID:
871
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HSP47/SERPINH1 antibody (CAB13474) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
