Serpinh1 Antibody (PACO29852)
- SKU:
- PACO29852
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Serpinh1 Antibody (PACO29852)
The Serpinh1 Polyclonal Antibody (PAC029852) is a vital tool for research involving Serpinh1, a protein involved in collagen biosynthesis and extracellular matrix organization. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to the Serpinh1 protein, this antibody enables precise detection and analysis in various cell types, making it an essential component for studies in the fields of molecular biology and disease research.
Serpinh1, also known as heat shock protein 47, plays a crucial role in the folding and processing of collagens, contributing to the maintenance of structural integrity in tissues. Its involvement in collagen metabolism makes it a key target for research into fibrotic diseases, connective tissue disorders, and other conditions affecting the extracellular matrix. By understanding the function and regulation of Serpinh1, researchers can develop new strategies for treating and managing these debilitating diseases.
| Antibody Name: | Serpinh1 Antibody (PACO29852) |
| Antibody SKU: | PACO29852 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse Serpin H1 protein (18-417AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Serpinh1 antibody at 6µg/ml + Jurkat whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 47 kDa Observed band size: 47 kDa . |
| Background: | Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. |
| Synonyms: | Serpin H1 (47 kDa heat shock protein) (Collagen-binding protein) (Colligin) (Serine protease inhibitor J6), Serpinh1, Cbp1 Hsp47 |
| UniProt Protein Function: | SERPINH1: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. Defects in SERPINH1 are the cause of osteogenesis imperfecta type 10 (OI10). A connective tissue disorder characterized by bone fragility, low bone mass, bowing of limbs due to multiple fractures, short limb dwarfism and blue sclerae. Belongs to the serpin family.Cellular Component: extracellular space; endoplasmic reticulum; cytoplasm; ER-Golgi intermediate compartmentMolecular Function: serine-type endopeptidase inhibitor activity; collagen binding; protein binding; unfolded protein bindingBiological Process: collagen fibril organization; protein maturation; collagen biosynthetic process |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P19324 |
| NCBI GenInfo Identifier: | 161353504 |
| NCBI Gene ID: | 12406 |
| NCBI Accession: | NP_001104513.1 |
| UniProt Secondary Accession: | P19324,Q5U4D0 |
| UniProt Related Accession: | P19324 |
| Molecular Weight: | |
| NCBI Full Name: | serpin H1 |
| NCBI Synonym Full Names: | serine (or cysteine) peptidase inhibitor, clade H, member 1 |
| NCBI Official Symbol: | Serpinh1Â Â |
| NCBI Official Synonym Symbols: | J6; Cbp1; Cbp2; gp46; Hsp47; BERF-1; Serpinh2Â Â |
| NCBI Protein Information: | serpin H1 |
| UniProt Protein Name: | Serpin H1 |
| UniProt Synonym Protein Names: | 47 kDa heat shock protein; Collagen-binding protein; Colligin; Serine protease inhibitor J6 |
| Protein Family: | |
| UniProt Gene Name: | Serpinh1Â Â |
| UniProt Entry Name: | SERPH_MOUSE |
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