The HSP47 Rabbit Monoclonal Antibody is a cutting-edge tool for researchers studying heat shock protein 47 (HSP47), a key player in the regulation of collagen biosynthesis. This antibody, produced using rabbit monoclonal technology, has high specificity and sensitivity for detecting HSP47 in human samples, making it a valuable asset for Western blot applications.HSP47 is essential for the proper folding and secretion of collagen, a critical component of the extracellular matrix that provides structural support to tissues and organs. Dysregulation of HSP47 has been implicated in various diseases, including fibrosis and cancer, making it a promising target for therapeutic interventions.
By enabling precise detection and analysis of HSP47 in different cell types, this antibody facilitates in-depth research into the role of HSP47 in health and disease.Researchers in the fields of molecular biology, cell biology, and biomedical science will benefit from the use of the HSP47 Rabbit Monoclonal Antibody in their studies. Its ability to target and detect HSP47 with high specificity and sensitivity makes it an essential tool for unraveling the complex mechanisms underlying collagen metabolism and its implications for various pathological conditions. Unlock new insights into HSP47 biology with this innovative antibody.
Product Name:
HSP47/SERPINH1 Rabbit Monoclonal Antibody
SKU:
CAB11698
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 319-418 of human HSP47/SERPINH1 (P50454).
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
Purification Method:
Affinity purification
Gene ID:
871
Clone Number:
ARC0681
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using HSP47/SERPINH1 Rabbit mAb (CAB11698) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
