The Serping1 Polyclonal Antibody (CAB1717) is a powerful tool for researchers studying Serping1, a critical component in the regulation of the complement system and inflammation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting. By binding specifically to the Serping1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in immunology and inflammatory disorders.Serping1, also known as C1 inhibitor, is a key player in controlling the complement system, which is essential for immune response regulation and defense against pathogens.
Dysregulation of Serping1 can result in autoimmune diseases, hereditary angioedema, and other inflammatory conditions. Research into Serping1 is crucial for understanding the mechanisms underlying these disorders and developing targeted therapies to address them.Overall, the Serping1 Polyclonal Antibody (CAB1717) offers researchers a reliable tool for investigating the role of Serping1 in immune regulation and inflammation, with the potential to advance our understanding of various diseases and guide the development of new treatment strategies.
Product Name:
SERPING1 Rabbit Polyclonal Antibody
SKU:
CAB1717
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 201-500 of human SERPING1 (NP_001027466.1).
This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its encoded protein, C1 inhibitor, inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. It is synthesized in the liver, and its deficiency is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.
Purification Method:
Affinity purification
Gene ID:
710
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Human plasma, using SERPING1 antibody (CAB1717) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
