The SERPING1 Polyclonal Antibody (CAB12407) is a valuable tool for researchers studying SERPING1, a protein involved in the regulation of the complement system, a key component of the immune response. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SERPING1 protein, this antibody allows for the detection and analysis of SERPING1 in various cell types, making it an essential reagent for studies in immunology and inflammatory diseases.SERPING1, also known as C1 inhibitor, plays a crucial role in regulating the complement system to prevent excessive inflammation and tissue damage.
Dysregulation of SERPING1 has been implicated in diseases such as hereditary angioedema, a rare genetic disorder characterized by recurrent episodes of swelling. Research on SERPING1 is essential for understanding the mechanisms underlying these conditions and developing targeted therapies to manage them effectively.Overall, the SERPING1 Polyclonal Antibody (CAB12407) is a reliable tool for researchers investigating the role of SERPING1 in immune regulation and inflammatory diseases, providing valuable insights that could lead to the development of novel treatment strategies in the future.
Product Name:
SERPING1 Rabbit Polyclonal Antibody
SKU:
CAB12407
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-500 of human SERPING1 (NP_000053.2).
This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its encoded protein, C1 inhibitor, inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. It is synthesized in the liver, and its deficiency is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.
Purification Method:
Affinity purification
Gene ID:
710
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse heart, using SERPING1 Rabbit pAb (CAB12407) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
