The Serpinf1 Polyclonal Antibody (CAB16946) is a research tool designed for studying Serpinf1, a member of the serine protease inhibitor (serpin) superfamily implicated in various biological processes. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. Serpinf1, also known as Pigment epithelium-derived factor (PEDF), is a multifunctional protein with anti-angiogenic, neurotrophic, and anti-inflammatory properties. Its diverse roles in regulating cell growth, differentiation, and survival make it a key molecule of interest in research areas such as angiogenesis, neuroprotection, and inflammation.
The Serpinf1 Polyclonal Antibody enables specific detection and analysis of Serpinf1 protein in different cell types, making it a valuable tool for studies in molecular biology, neurobiology, and cancer research. Understanding the function and regulation of Serpinf1 is essential for advancing knowledge of its involvement in various physiological and pathological processes, paving the way for potential therapeutic interventions targeting this protein.
Product Name:
PEDF/SERPINF1 Rabbit Polyclonal Antibody
SKU:
CAB16946
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 141-240 of human PEDF/SERPINF1 (NP_002606.3).
This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI.
Purification Method:
Affinity purification
Gene ID:
5176
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PEDF/PEDF/SERPINF1 Rabbit pAb (CAB16946) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
