The SerpinF1 Polyclonal Antibody (CAB16945) is a valuable tool for researchers studying SerpinF1, a member of the serine protease inhibitor family known for its role in regulating inflammation and immune responses. This rabbit-derived antibody is highly specific for human samples and has been validated for use in Western blot applications.SerpinF1, also known as monocyte neutrophil inhibitory factor (MONFI), is a key player in the inflammatory response, acting to inhibit the activity of proteases involved in inflammatory processes. Dysregulation of SerpinF1 has been implicated in various diseases, including cancer and autoimmune disorders, making it a promising target for therapeutic interventions.
By utilizing the SerpinF1 Polyclonal Antibody, researchers can detect and analyze SerpinF1 expression in different cell types, furthering our understanding of its role in immune regulation and inflammation. This antibody is a valuable tool for studies in immunology, cancer biology, and inflammatory diseases, paving the way for potential therapeutic advancements in these areas.
Product Name:
PEDF/SERPINF1 Rabbit Polyclonal Antibody
SKU:
CAB16945
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 301-400 of human PEDF/SERPINF1 (NP_002606.3).
Human serum,U2OS,Mouse spleen,Mouse kidney,Rat liver
Cellular Localization:
Melanosome, Secreted.
Calculated MW:
46kDa
Observed MW:
46kDa
This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI.
Purification Method:
Affinity purification
Gene ID:
5176
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PEDF/PEDF/SERPINF1 Rabbit pAb (CAB16945) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
