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Serpinf1 Antibody (PACO29848)

SKU:
PACO29848
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$407
Frequently bought together:

Description

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Serpinf1 Antibody (PACO29848)

The SerpinF1 Antibody (PAC029848) is a vital tool for researchers studying SerpinF1, a serine protease inhibitor involved in various biological processes. This polyclonal antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for use in Western blot applications. By targeting SerpinF1, researchers can investigate its role in regulating protease activity and its impact on conditions like inflammation and cancer.SerpinF1, also known as PEDF (Pigment Epithelium-Derived Factor), has been shown to possess antiangiogenic and neurotrophic properties, making it a promising target for therapeutic intervention in diseases like diabetic retinopathy and cancer.

By understanding the mechanisms through which SerpinF1 functions, researchers can develop novel treatment strategies aimed at modulating its activity for therapeutic benefit. This antibody provides a valuable tool for exploring the role of SerpinF1 in various biological processes, making it an essential component of studies in immunology and cancer research.

Antibody Name:Serpinf1 Antibody (PACO29848)
Antibody SKU:PACO29848
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Rat
Immunogen:Recombinant Rat Alpha-2 antiplasmin protein (20-418AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:Pigment epithelium-derived factor (PEDF) (Caspin) (Serpin F1) (Stromal cell-derived factor 3) (SDF-3), Serpinf1, Pedf Sdf3
UniProt Protein Function:PEDF: a secreted neurotrophic protein that induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity. Extracellular phosphorylation enhances antiangiogenic activity.
UniProt Protein Details:

Protein type:Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: axon; axon hillock; basement membrane; cell soma; extracellular matrix; extracellular region; extracellular space; perinuclear region of cytoplasm

Molecular Function:serine-type endopeptidase inhibitor activity

Biological Process: aging; kidney development; negative regulation of angiogenesis; negative regulation of inflammatory response; ovulation cycle; positive regulation of neurogenesis; response to acidity; response to arsenic; retina development in camera-type eye; short-term memory

NCBI Summary:mouse homolog is a proteinase inhibitor involved in vascularization [RGD, Feb 2006]
UniProt Code:Q80ZA3
NCBI GenInfo Identifier:29293811
NCBI Gene ID:287526
NCBI Accession:NP_808788.1
UniProt Secondary Accession:Q80ZA3,F1LSW0,
Molecular Weight:46,465 Da
NCBI Full Name:pigment epithelium-derived factor
NCBI Synonym Full Names:serpin family F member 1
NCBI Official Symbol:Serpinf1  
NCBI Official Synonym Symbols:Pedf; Dmrs91  
NCBI Protein Information:pigment epithelium-derived factor
UniProt Protein Name:Alpha-2 antiplasmin
UniProt Synonym Protein Names:Alpha-2 antiplasmin
UniProt Gene Name:Serpinf1  

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