The Serpine1 Polyclonal Antibody (CAB6211) is a specialized tool for researchers studying the Serpine1 protein, also known as Plasminogen Activator Inhibitor-1 (PAI-1). This antibody, produced in rabbits, has high specificity and reactivity with human samples, making it a reliable choice for Western blot applications.Serpine1 is a key regulator of the fibrinolytic system, playing a crucial role in the inhibition of tissue plasminogen activators. Dysregulation of Serpine1 has been linked to various pathologies, including cardiovascular diseases, cancer metastasis, and fibrotic disorders.
The antibody's ability to bind to Serpine1 enables researchers to detect and analyze the protein in different cell types, making it an essential tool in studies related to thrombosis, metastasis, and fibrosis.By using the Serpine1 Polyclonal Antibody, researchers can gain valuable insights into the molecular mechanisms underlying Serpine1's functions, paving the way for the development of novel therapeutic strategies targeting Serpine1-related pathologies. Its reliability and specificity make it a valuable asset in immunology, oncology, and cardiovascular research.
Product Name:
PAI-1/Serpin E1 Rabbit Polyclonal Antibody
SKU:
CAB6211
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 24-199 of human PAI-1/Serpin E1 (NP_000593.1).
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. The protein also functions as a component of innate antiviral immunity. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia.
Purification Method:
Affinity purification
Gene ID:
5054
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat placenta, using PAI-1/Serpin E1 Rabbit pAb (CAB6211) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
