The Heparin Cofactor 2 Polyclonal Antibody (CAB5848) is specifically designed for researchers studying Heparin Cofactor 2, a key protein involved in blood coagulation regulation. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the Heparin Cofactor 2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for investigating coagulation pathways and related disorders.
Heparin Cofactor 2 is known for its role in enhancing the anticoagulant activity of heparin, a crucial process in maintaining proper blood clotting and preventing thrombosis. Research on Heparin Cofactor 2 is relevant to understanding coagulation disorders, cardiovascular diseases, and other conditions related to blood clot formation. The use of this antibody in studies can provide valuable insights into the mechanisms underlying these diseases, potentially leading to the development of new therapeutic strategies targeting Heparin Cofactor 2.
Product Name:
SERPIND1 Rabbit Polyclonal Antibody
SKU:
CAB5848
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-290 of human SERPIND1 (NP_000176.2).
endoplasmic reticulum lumen, extracellular exosome, extracellular region, extracellular space
Calculated MW:
57kDa
Observed MW:
57-69kDa
This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency.
Purification Method:
Affinity purification
Gene ID:
3053
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SERPIND1 antibody (CAB5848) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
