SERPINC1 Rabbit Monoclonal Antibody (CAB11249)
- SKU:
- CAB11249
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cardiovascular
Description
Product Name: | SERPINC1 Rabbit Monoclonal Antibody |
SKU: | CAB11249 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SERPINC1 (P01008). |
Sequence: | MYSN VIGT VTSG KRKV YLLS LLLI GFWD CVTC HGSP VDIC TAKP RDIP MNPM CIYR SPEK KATE DEGS EQKI PEAT NRRV WELS KANS RFAT TFYQ HLAD |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | AT3; AT3D; ATIII; THPH7; ATIII-R2; ATIII-T1; ATIII-T2; SERPINC1 |
Positive Sample: | HepG2,K-562,Rat liver,Mouse plasma,Rat plasma,Human plasma |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular space. |
Calculated MW: | 58kDa |
Observed MW: | 58kDa |
The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19).
Purification Method: | Affinity purification |
Gene ID: | 462 |
Clone Number: | ARC0559 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |