The Serpin B6 Polyclonal Antibody (CAB9944) is a crucial tool for research involving Serpin B6, a member of the serine protease inhibitor superfamily with diverse biological functions. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been extensively validated for use in Western blot applications. It specifically targets the Serpin B6 protein, enabling its detection and analysis in various cell types.Serpin B6, also known as placental thrombin inhibitor, is involved in the regulation of blood coagulation and inflammation. Its role in inhibiting thrombin activity highlights its potential importance in various physiological and pathological processes, including thrombosis, hemostasis, and inflammation.
Research into Serpin B6 can provide valuable insights into these complex biological mechanisms and potentially lead to the development of novel therapeutic interventions in related diseases.By utilizing the Serpin B6 Polyclonal Antibody, researchers can further explore the functions and regulation of this important protein, advancing our understanding of its role in health and disease. Its application in immunology and coagulation studies makes it a valuable asset in investigations related to thrombotic disorders, inflammatory conditions, and other diseases where Serpin B6 may be implicated.
Product Name:
SERPINB6 Rabbit Polyclonal Antibody
SKU:
CAB9944
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human SERPINB6 (NP_004559.4).
The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5269
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SERPINB6 antibody (CAB9944) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
