Anti-SERPINB5 Antibody (CAB14042)
- SKU:
- CAB14042
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Anti-SERPINB5 Antibody (CAB14042)
The SerpinB5 Polyclonal Antibody (CAB14042) is a valuable tool for researchers studying SerpinB5, a serine protease inhibitor that plays a role in various biological processes, including cell proliferation, apoptosis, and tumor suppression. This antibody, generated in rabbits, shows high specificity and sensitivity when used in Western blot applications with human samples.SerpinB5, also known as maspin, is known for its ability to suppress tumor growth and metastasis in multiple types of cancer. Its dynamic expression in various tissues and its association with cancer progression make it a promising target for further investigation in oncology research.
The SerpinB5 Polyclonal Antibody enables researchers to detect and analyze SerpinB5 expression levels in different cell types, providing valuable insights into its functions and potential therapeutic implications.Overall, the SerpinB5 Polyclonal Antibody is a reliable tool for researchers interested in unraveling the complexities of SerpinB5 biology and its implications in cancer development and progression. Its high reactivity and specificity make it suitable for a wide range of immunological and cancer research studies.
| Antibody Name: | Anti-SERPINB5 Antibody |
| Antibody SKU: | CAB14042 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-189 of human SERPINB5 (NP_002630.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-29, NIH/3T3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-189 of human SERPINB5 (NP_002630.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EKEP LGNV LFSP ICLS TSLS LAQV GAKG DTAN EIGQ VLHF ENVK DVPF GFQT VTSD VNKL SSFY SLKL IKRL YVDK SLNL STEF ISST KRPY AKEL ETVD FKDK LEET KGQI NNSI KDLT DGHF ENIL ADNS VNDQ TKIL VVNA AYFV GKWM KKFS ESET KECP FRVN K |
| Gene ID: | 5268 |
| Uniprot: | P36952 |
| Cellular Location: | Secreted, extracellular space |
| Calculated MW: | 25kDa/42kDa |
| Observed MW: | 43kDa |
| Synonyms: | SERPINB5, PI5, maspin, serpin B5 |
| Background: |
| UniProt Protein Function: | maspin: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Interacts with IRF6. Normal mammary epithelial cells. Belongs to the serpin family. Ov-serpin subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 18q21.33 Cellular Component: extracellular space; cytoplasm Molecular Function:serine-type endopeptidase inhibitor activity; protein binding Biological Process: extracellular matrix organization and biogenesis; morphogenesis of an epithelium; cell motility; regulation of epithelial cell proliferation |
| UniProt Code: | P36952 |
| NCBI GenInfo Identifier: | 229462757 |
| NCBI Gene ID: | 5268 |
| NCBI Accession: | P36952.2 |
| UniProt Secondary Accession: | P36952,Q6N0B4, Q8WW89, B2R6Y4, |
| UniProt Related Accession: | P36952 |
| Molecular Weight: | 25,763 Da |
| NCBI Full Name: | Serpin B5 |
| NCBI Synonym Full Names: | serpin peptidase inhibitor, clade B (ovalbumin), member 5 |
| NCBI Official Symbol: | SERPINB5Â Â |
| NCBI Official Synonym Symbols: | PI5; maspin  |
| NCBI Protein Information: | serpin B5; PI-5; peptidase inhibitor 5; protease inhibitor 5 (maspin); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 |
| UniProt Protein Name: | Serpin B5 |
| UniProt Synonym Protein Names: | Maspin; Peptidase inhibitor 5; PI-5 |
| Protein Family: | Serpin |
| UniProt Gene Name: | SERPINB5Â Â |
| UniProt Entry Name: | SPB5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SERPINB5 antibody (CAB14042) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human stomach using SERPINB5 Antibody (CAB14042) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human rectum using SERPINB5 Antibody (CAB14042) at dilution of 1:200 (40x lens). |
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