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SERPINB5 Monoclonal Antibody [PAT2N6AT] (CPAB0546)

SKU:
CPAB0546
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PAT2N6AT
Applications:
WB
IF
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

SERPINB5 Monoclonal Antibody [PAT2N6AT] (CPAB0546)

The SerpinB5 Antibody (CPAB0546) is a valuable tool for researchers studying SerpinB5, a member of the serine protease inhibitor superfamily with known roles in cancer and inflammation. This polyclonal antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the SerpinB5 protein, this antibody allows for the detection and analysis of SerpinB5 levels in various cell types, making it an essential tool for studies in oncology and immunology.SerpinB5, also known as Maspin, is involved in the regulation of cell growth, apoptosis, and metastasis, particularly in cancer progression.

Its dual function as a tumor suppressor and an inhibitor of inflammatory responses highlights its potential as a therapeutic target for cancer and inflammatory diseases. Research into the mechanisms of SerpinB5 can provide valuable insights into the development of novel treatment strategies for these conditions.Overall, the SerpinB5 Antibody (CPAB0546) is a reliable reagent for investigating the functions of SerpinB5 in cellular processes associated with cancer and inflammation. Its specificity and sensitivity make it a valuable asset for scientists conducting cutting-edge research in these fields.

Product Name:SERPINB5 Antibody
Product Sku:CPAB0546
Size:5μg
Host Species:Mouse
Immunogen:Anti-human SERPINB5 mAb is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human SERPINB5 amino acids 1-375 purified from Ecoli.
Clone:PAT2N6AT.
Reactivity:Other bodies
Applications:Western Blot, Immunofluorescence, ELISA
Purification Method:SERPINB5 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:SERPINB5 (Maspin) is a tumor suppressor protein of the serine proteinase inhibitor family. Maspin plays a vital role in embryonic development through critical functions in cell adhesion. In addition, Maspin is present in normal breast and prostatic epithelial cells although down regulated in the particular carcinomas. SERPINB5 impedes the growth, invasion, and metastatic properties of mammary tumors as well as the invasive ability of pancreatic ductal adenocarcinoma cells. SERPINB5 being a breast tumor suppressor gene is a significant marker of the disease progression in breast neoplasms. Furthermore, high expression of maspin is linked to squamous cell carcinoma in non-small-cell lung cancer. Moreover, maspin expression has been directly linked with the biological aggressiveness of ovarian carcinoma. Maspin exhibits no serine protease inhibitory activity since it does not undergo the stressed to relaxed conformational transition typical of active serpins.
Synonyms:PI5, maspin, SERPINB5, serpin peptidase inhibitor clade B (ovalbumin) member 5, Serpin B5, Protease inhibitor 5.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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