The Serpina7 Polyclonal Antibody (CAB6313) is a powerful tool for researchers studying Serpina7, a serine proteinase inhibitor implicated in various physiological processes. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding to Serpina7, this antibody enables precise detection and analysis in different cell types, making it an excellent choice for studies in biochemistry and molecular biology.
Serpina7, also known as thyroxine-binding globulin, plays a crucial role in regulating the levels of thyroid hormones in the bloodstream. Its involvement in thyroid function makes it a compelling target for research in endocrinology and metabolism. Understanding the mechanisms of Serpina7 action is essential for developing potential therapies for thyroid disorders and other related conditions.
Product Name:
SERPINA7 Rabbit Polyclonal Antibody
SKU:
CAB6313
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 146-415 of human SERPINA7 (NP_000345.2).
There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
6906
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SERPINA7 antibody (CAB6313) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 30s.
