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SERPINA5 Antibody (PACO12108)

SKU:
PACO12108
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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SERPINA5 Antibody (PACO12108)

The SERPINA5 Polyclonal Antibody (PACO12108) is a valuable tool for studying SERPINA5, a protein involved in various physiological processes, including blood coagulation and inflammation. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the SERPINA5 protein, this antibody enables researchers to detect and analyze SERPINA5 expression in a variety of cell types, making it well-suited for investigations in the fields of hemostasis, thrombosis, and vascular biology.

SERPINA5, also known as Protein C inhibitor, plays a crucial role in regulating the activity of protein C, an important anticoagulant protein involved in controlling blood clotting. Dysregulation of SERPINA5 has been linked to various diseases, such as thrombosis, sepsis, and cardiovascular disorders. By studying the function of SERPINA5, researchers can gain insight into the mechanisms underlying these conditions and potentially identify new therapeutic targets for managing coagulation disorders and related complications.

Antibody Name:SERPINA5 Antibody (PACO12108)
Antibody SKU:PACO12108
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Human SERPINA5
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5;SERPINA5;PAI3;PCI;PLANH3;PROCI ;
UniProt Protein Function:SERPINA5: Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary- type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as an hydrophobic hormone carrier by its binding to retinoic acid. Belongs to the serpin family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: acrosomal membrane; external side of plasma membrane; extracellular region; extracellular space; membrane; protein complex

Molecular Function:acrosin binding; glycosaminoglycan binding; heparin binding; phosphatidylcholine binding; protease binding; protein binding; retinoic acid binding; serine-type endopeptidase inhibitor activity

Biological Process: blood coagulation; negative regulation of hydrolase activity; spermatogenesis

NCBI Summary:The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]
UniProt Code:P05154
NCBI GenInfo Identifier:322510122
NCBI Gene ID:5104
NCBI Accession:P05154.3
UniProt Secondary Accession:P05154,Q07616, Q9UG30,
UniProt Related Accession:P05154
Molecular Weight:45,675 Da
NCBI Full Name:Plasma serine protease inhibitor
NCBI Synonym Full Names:serpin family A member 5
NCBI Official Symbol:SERPINA5  
NCBI Official Synonym Symbols:PCI; PAI3; PAI-3; PCI-B; PROCI; PLANH3  
NCBI Protein Information:plasma serine protease inhibitor
UniProt Protein Name:Plasma serine protease inhibitor
UniProt Synonym Protein Names:Acrosomal serine protease inhibitor; Plasminogen activator inhibitor 3; PAI-3; PAI3; Protein C inhibitor; PCI; Serpin A5
Protein Family:Plasma serine protease inhibitor
UniProt Gene Name:SERPINA5  
UniProt Entry Name:IPSP_HUMAN

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