The Serpina3 Polyclonal Antibody (CAB2803) is a vital tool for researchers studying the Serpina3 protein, which is involved in various biological processes including inflammation regulation and protease inhibition. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the Serpina3 protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an essential component for studies in immunology, cancer research, and beyond.
Serpina3, also known as alpha-1-antichymotrypsin, plays a crucial role in regulating inflammatory responses and modulating protease activity. Its involvement in these processes positions it as a promising target for research on diseases such as cancer, autoimmune disorders, and inflammatory conditions. By gaining a deeper understanding of the functions of Serpina3, researchers can potentially develop new therapeutic strategies that target this protein to improve treatment outcomes in various disease settings.
The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.
Purification Method:
Affinity purification
Gene ID:
12
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of Human plasma, using Alpha-1 Antichymotrypsin (SERPINA3) antibody (CAB2803) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
