The SERPINA3 Polyclonal Antibody (CAB1021) is a valuable tool for researchers studying SERPINA3, a protein involved in various physiological processes, such as inflammation, oxidative stress, and tissue repair. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.SERPINA3, also known as alpha-1-antichymotrypsin, is a serine protease inhibitor believed to play a role in regulating protease activity and protecting tissues from damage. Its diverse functions in the body make it a promising target for research in fields such as immunology, oncology, and neurology.
By utilizing the SERPINA3 Polyclonal Antibody, researchers can detect and quantify SERPINA3 protein levels in various cell types, providing valuable insights into its role in different physiological and pathological conditions. This antibody is an essential tool for investigating the molecular mechanisms underlying SERPINA3-related diseases and developing potential therapeutic interventions targeting this protein.
Recombinant fusion protein containing a sequence corresponding to amino acids 24-423 of human Alpha-1 Antichymotrypsin (Alpha-1 Antichymotrypsin (SERPINA3)) (NP_001076.2).
The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.
Purification Method:
Affinity purification
Gene ID:
12
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Alpha-1 Antichymotrypsin (SERPINA3) Rabbit pAb (CAB1021) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
