SERPINA11 Antibody (PACO57276)
- SKU:
- PACO57276
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SERPINA11 Antibody (PACO57276)
The SERPINA11 Polyclonal Antibody (PAC05726) is a valuable tool for researchers studying SERPINA11, a member of the serpin family of proteins involved in protease inhibition. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting SERPINA11 in human samples, making it suitable for use in various research applications including Western blot analysis. By binding to the SERPINA11 protein, this antibody enables researchers to study its function and expression levels in different cell types.
SERPINA11, also known as alpha-1-antitrypsin, is involved in regulating protease activity, making it an important player in processes such as blood clotting and inflammation. Dysregulation of SERPINA11 has been implicated in various diseases, including liver and lung disorders, highlighting its potential as a therapeutic target. By elucidating the role of SERPINA11 in these conditions, researchers can potentially develop novel treatment strategies to address these health issues.
| Antibody Name: | SERPINA11 Antibody (PACO57276) |
| Antibody SKU: | PACO57276 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Serpin A11 protein (279-394AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: MCF-7 whole cell lysate, Raji whole cell lysate, HepG2 whole cell lysate. All lanes: SERPINA11 antibody at 5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 47 kDa. Observed band size: 47 kDa. |
| Background: | extracellular space, serine-type endopeptidase inhibitor activity |
| Synonyms: | Serpin A11, SERPINA11 |
| UniProt Protein Function: | SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11q12.1 Cellular Component: extracellular space; extracellular region Molecular Function:serine-type endopeptidase inhibitor activity; protein binding Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; blood coagulation, intrinsic pathway; complement activation, classical pathway; aging Disease: Complement Component 4, Partial Deficiency Of; Angioedema, Hereditary, Type I |
| UniProt Code: | Q86U17 |
| NCBI GenInfo Identifier: | 122937297 |
| NCBI Gene ID: | 256394 |
| NCBI Accession: | NP_001073920 |
| UniProt Secondary Accession: | Q86U17,Q86U17, |
| UniProt Related Accession: | Q86U17 |
| Molecular Weight: | 47kDa |
| NCBI Full Name: | serpin A11 |
| NCBI Synonym Full Names: | serpin family A member 11 |
| NCBI Official Symbol: | SERPINA11Â Â |
| NCBI Protein Information: | serpin A11 |
| UniProt Protein Name: | Plasma protease C1 inhibitor |
| UniProt Synonym Protein Names: | C1 esterase inhibitor; C1-inhibiting factor; Serpin G1 |
| Protein Family: | Plasma protease C1 inhibitor |
| UniProt Gene Name: | SERPING1Â Â |
| UniProt Entry Name: | IC1_HUMAN |
| Antibodies | ELISA Kits |
| SERPINA11 Antibody (PACO03783) | Human Serpin A11 / SERPINA11 ELISA Kit |
| Human Serpin A11 (SERPINA11) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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