SERPINA11 Antibody (PACO20443)
- SKU:
- PACO20443
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SERPINA11 Antibody (PACO20443)
The Serpina11 Polyclonal Antibody (PAC020443) is a valuable tool for researchers studying Serpina11, a serine protease inhibitor involved in various physiological processes, including inflammation and immune responses. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the Serpina11 protein, researchers can detect and analyze its expression in different cell types, making it an essential tool for studies in immunology and inflammatory diseases.
Serpina11, also known as alpha-1-antitrypsin, plays a crucial role in regulating the activity of proteolytic enzymes involved in inflammation and tissue damage. Its dysregulation has been linked to diseases such as chronic obstructive pulmonary disease (COPD) and liver cirrhosis, making it a promising target for therapeutic interventions. By understanding the function of Serpina11, researchers can develop new strategies for treating these conditions and improving patient outcomes.
| Antibody Name: | SERPINA11 Antibody (PACO20443) |
| Antibody SKU: | PACO20443 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human SERPINA11 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20443(SERPINA11 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The protein belongs to the serpin family. SERPINA11 has serine-type endopeptidase inhibitor activity, negative regulation of endopeptidase activity, regulation of proteolysis, serine-type endopeptidase inhibitor activity. |
| Synonyms: | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 |
| UniProt Protein Function: | SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11q12.1 Cellular Component: extracellular space; extracellular region Molecular Function:serine-type endopeptidase inhibitor activity; protein binding Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; blood coagulation, intrinsic pathway; complement activation, classical pathway; aging Disease: Complement Component 4, Partial Deficiency Of; Angioedema, Hereditary, Type I |
| UniProt Code: | Q86U17 |
| NCBI GenInfo Identifier: | 122937297 |
| NCBI Gene ID: | 256394 |
| NCBI Accession: | NP_001073920 |
| UniProt Secondary Accession: | Q86U17,Q86U17, |
| UniProt Related Accession: | Q86U17 |
| Molecular Weight: | 47kDa |
| NCBI Full Name: | serpin A11 |
| NCBI Synonym Full Names: | serpin family A member 11 |
| NCBI Official Symbol: | SERPINA11Â Â |
| NCBI Protein Information: | serpin A11 |
| UniProt Protein Name: | Plasma protease C1 inhibitor |
| UniProt Synonym Protein Names: | C1 esterase inhibitor; C1-inhibiting factor; Serpin G1 |
| Protein Family: | Plasma protease C1 inhibitor |
| UniProt Gene Name: | SERPING1Â Â |
| UniProt Entry Name: | IC1_HUMAN |
| Antibodies | ELISA Kits |
| SERPINA11 Antibody (PACO03783) | Human Serpin A11 / SERPINA11 ELISA Kit |
| Human Serpin A11 (SERPINA11) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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SERPINA11 Antibody (PACO20444)
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Human Serpin A11 / SERPINA11 ELISA Kit
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Mouse Serpin A11 (Serpina11) ELISA Kit (MOEB2323)
