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SERPINA11 Antibody (PACO03783)

SKU:
PACO03783
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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SERPINA11 Antibody (PACO03783)

The SERPINA11 Polyclonal Antibody (PACO03783) is a valuable tool for researchers studying SERPINA11, a member of the serine protease inhibitor superfamily. This antibody, generated in rabbits, has been shown to be highly specific in detecting SERPINA11 in human samples, and is validated for use in Western blot applications. By binding to the SERPINA11 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for research in the fields of immunology and cancer.

SERPINA11, also known as Alpha-1-antitrypsin-like protein, is involved in regulating protease activity and inflammatory responses in the body. Its role in immune response modulation and inflammation makes it a promising target for research in various diseases, including cancer and inflammatory disorders. By understanding the function of SERPINA11, researchers can develop better therapies and treatment strategies for these conditions by targeting its activity in immune regulation.

Antibody Name:SERPINA11 Antibody
Antibody SKU:PACO03783
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the Internal region of human Serpin A11.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:SERPINA11; Serpin A11
UniProt Protein Function:SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: extracellular space; extracellular region

Molecular Function:serine-type endopeptidase inhibitor activity; protein binding

Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; blood coagulation, intrinsic pathway; complement activation, classical pathway; aging

Disease: Complement Component 4, Partial Deficiency Of; Angioedema, Hereditary, Type I

UniProt Code:Q86U17
NCBI GenInfo Identifier:122937297
NCBI Gene ID:256394
NCBI Accession:NP_001073920
UniProt Secondary Accession:Q86U17,Q86U17,
UniProt Related Accession:Q86U17
Molecular Weight:47kDa
NCBI Full Name:serpin A11
NCBI Synonym Full Names:serpin family A member 11
NCBI Official Symbol:SERPINA11  
NCBI Protein Information:serpin A11
UniProt Protein Name:Plasma protease C1 inhibitor
UniProt Synonym Protein Names:C1 esterase inhibitor; C1-inhibiting factor; Serpin G1
Protein Family:Plasma protease C1 inhibitor
UniProt Gene Name:SERPING1  
UniProt Entry Name:IC1_HUMAN

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