The SERPINA1 Rabbit Monoclonal Antibody (CAB4966) is a powerful tool for researchers studying SERPINA1, a key protein involved in the regulation of protease activity and inflammation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in various applications such as Western blotting and immunohistochemistry.SERPINA1, also known as alpha-1-antitrypsin, is a crucial inhibitor of proteases that can cause tissue damage. Dysregulation of SERPINA1 has been implicated in a variety of diseases, including emphysema, liver cirrhosis, and even certain cancers.
By targeting SERPINA1 with this antibody, researchers can gain valuable insights into its role in disease pathogenesis and potentially identify new therapeutic targets.Overall, the SERPINA1 Rabbit Monoclonal Antibody (CAB4966) is an essential tool for any scientist looking to delve deeper into the molecular mechanisms governing inflammation and protease activity, with potential implications for the development of novel treatments for a range of diseases.
Endoplasmic reticulum, Secreted, extracellular matrix, extracellular space
Calculated MW:
47kDa
Observed MW:
45kDa
The protein encoded by this gene is a serine protease inhibitor belonging to the serpin superfamily whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. This protein is produced in the liver, the bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth cells of the gut. Defects in this gene are associated with chronic obstructive pulmonary disease, emphysema, and chronic liver disease. Several transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5265
Clone Number:
ARC1212
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Alpha-1 Antitrypsin (Alpha-1 Antitrypsin (SERPINA1)) Rabbit mAb (CAB4966) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
