The Serpina1 Polyclonal Antibody (CAB12481) is a essential tool for researchers studying Serpina1, a protein involved in regulating protease activity and inflammation. Developed using rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding specifically to the Serpina1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an invaluable asset for studies in immunology, inflammation, and disease research.
Serpina1, also known as alpha-1 antitrypsin, is a key player in the regulation of protease activity and inflammation in the body. Dysregulation of Serpina1 has been implicated in a number of diseases, including chronic obstructive pulmonary disease (COPD) and liver disease. By studying the role of Serpina1 using this antibody, researchers can gain valuable insight into the mechanisms underlying these conditions and potentially identify new therapeutic targets for treatment.
Recombinant fusion protein containing a sequence corresponding to amino acids 25-315 of human Alpha-1 Antitrypsin (Alpha-1 Antitrypsin (SERPINA1)) (NP_000286.3).
The protein encoded by this gene is a serine protease inhibitor belonging to the serpin superfamily whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. This protein is produced in the liver, the bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth cells of the gut. Defects in this gene are associated with chronic obstructive pulmonary disease, emphysema, and chronic liver disease. Several transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5265
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Alpha-1 Antitrypsin (Alpha-1 Antitrypsin (SERPINA1)) antibody (CAB12481) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
