The SERP1 Polyclonal Antibody (PACO12104) is specifically designed for research involving SERP1, a protein involved in the regulation of protease activity in the endoplasmic reticulum. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot and immunofluorescence applications. By binding to the SERP1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal tool for researchers studying protein folding, ER stress, and proteostasis.SERP1 is a key player in maintaining protein homeostasis within cells, particularly in the ER where proper folding and processing of proteins occurs.
Dysregulation of SERP1 has been implicated in diseases such as neurodegenerative disorders, diabetes, and cardiovascular diseases. Understanding the role of SERP1 in these conditions is crucial for developing targeted therapies aimed at restoring protein equilibrium and preventing cellular dysfunction. By utilizing the SERP1 Polyclonal Antibody, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic strategies.
stress-associated endoplasmic reticulum protein 1;SERP1;MGC117327;MGC133321;MGC133322;RAMP4 ;
UniProt Protein Function:
RAMP4: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins. Belongs to the RAMP4 family.Protein type: Chaperone; Membrane protein, integralChromosomal Location of Human Ortholog: 3q25.1Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; cytoplasmic microtubule; integral to membrane; ribosomeBiological Process: positive regulation of translation; unfolded protein response; multicellular organismal aging; protein modification process; positive regulation of insulin secretion; protein amino acid glycosylation; glucose metabolic process; positive regulation of organ growth; post-embryonic development; positive regulation of growth hormone secretion; protein transport; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; plasma membrane organization and biogenesis; response to stress; skeletal development; muscle morphogenesis
