The Serglycin Polyclonal Antibody (CAB6951) is a valuable tool for researchers studying Serglycin, a proteoglycan involved in immune cell function and inflammation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to Serglycin protein, this antibody allows for accurate detection and analysis in various cell types, making it ideal for studies in immunology and cancer research.Serglycin is known for its role in storing and transporting various proteases, cytokines, and growth factors within immune cells, contributing to processes such as immune response regulation and tissue remodeling.
Dysregulation of Serglycin expression has been implicated in conditions such as inflammation, tumor progression, and autoimmune diseases. Therefore, investigating the function and regulation of Serglycin is crucial for understanding its potential as a therapeutic target in various disease states.Overall, the Serglycin Polyclonal Antibody (CAB6951) provides researchers with a reliable tool for studying the role of Serglycin in immune cell biology and its implications in disease pathology. Its high specificity and sensitivity make it a valuable asset for in-depth investigations in the field of immunology and cancer research.
Product Name:
SRGN Rabbit Polyclonal Antibody
SKU:
CAB6951
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 28-158 of human SRGN (NP_002718.2).
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5552
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from THP-1 cells, using SRGN Rabbit pAb (CAB6951) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
