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SERF1A Antibody (PACO59884)

SKU:
PACO59884
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€359

Description

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SERF1A Antibody (PACO59884)

The SERF1A Monoclonal Antibody (PACO59884) is a valuable tool for researchers studying SERF1A, a protein involved in stress response pathways and proteostasis. This antibody, produced using recombinant technology, specifically targets SERF1A in human samples and is suitable for use in Western blot and immunofluorescence applications.SERF1A, also known as Stress associated endoplasmic reticulum protein 1, is a key player in maintaining protein homeostasis under stress conditions, making it a crucial target for research in neurodegenerative diseases, cancer, and aging. By understanding the function and regulation of SERF1A, researchers can uncover novel therapeutic targets for a wide range of conditions related to protein misfolding and aggregation.

The SERF1A Monoclonal Antibody (PACO59884) provides reliable and specific detection of SERF1A in various cell types, making it an essential tool for investigating the role of this protein in cellular stress responses and disease pathology. Whether studying basic cellular mechanisms or exploring potential therapeutic interventions, this antibody is a valuable asset for researchers in the fields of cell biology and molecular medicine.

Antibody Name:SERF1A Antibody (PACO59884)
Antibody SKU:PACO59884
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:Human
Immunogen:Recombinant Human Small EDRK-rich factor 1 protein (1-74AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageIHC image of PACO59884 diluted at 1:300 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:nervous system development
Synonyms:Small EDRK-rich factor 1 (Protein 4F5) (h4F5) (SMA modifier 1), SERF1A; SERF1B, FAM2A SERF1 SMAM1; FAM2B SERF1 SMAM1
UniProt Protein Function:SERF1: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The duplication region includes both a telomeric and a centromeric copy of this gene. Deletions of this gene, the telomeric copy, often accompany deletions of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients, and so it is thought that this gene may be a modifier of the SMA phenotype. The function of this protein is not known; however, it bears low-level homology with the RNA-binding domain of matrin-cyclophilin, a protein which colocalizes with small nuclear ribonucleoproteins (snRNPs) and the SMN1 gene product. Alternatively spliced transcripts have been documented but it is unclear whether alternative splicing occurs for both the centromeric and telomeric copies of the gene. [provided by RefSeq, Jul 2008]Chromosomal Location of Human Ortholog: 5q13Biological Process: nervous system development
UniProt Protein Details:
NCBI Summary:This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is the centromeric copy which is identical to the telomeric copy. Alternatively spliced transcripts have been documented but it is unclear whether alternative splicing occurs for both the centromeric and telomeric copies of the gene. The gene encodes a protein of unknown function which bears low-level homology with the RNA-binding domain of matrin-cyclophilin, a protein which colocalizes with small nuclear ribonucleoproteins (snRNPs) and the SMN1 gene product. [provided by RefSeq, Jul 2008]
UniProt Code:O75920
NCBI GenInfo Identifier:296010886
NCBI Gene ID:728492
NCBI Accession:NP_001171558.1
UniProt Secondary Accession:O75920,O75919, Q52LK5, B7ZKM2
UniProt Related Accession:O75920
Molecular Weight:7,336 Da
NCBI Full Name:small EDRK-rich factor 1 isoform 1
NCBI Synonym Full Names:small EDRK-rich factor 1B (centromeric)
NCBI Official Symbol:SERF1B  
NCBI Official Synonym Symbols:h4F5; FAM2B; H4F5C  
NCBI Protein Information:small EDRK-rich factor 1
UniProt Protein Name:Small EDRK-rich factor 1
UniProt Synonym Protein Names:Protein 4F5; h4F5; SMA modifier 1
Protein Family:
UniProt Gene Name:SERF1A  
UniProt Entry Name:SERF1_HUMAN
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