The Sequestosome-1 Polyclonal Antibody (CAB7758) is a valuable tool for researchers studying the protein sequestosome-1, also known as SQSTM1 or p62. This antibody, generated in rabbits, is highly specific and reactive to human samples, making it ideal for use in Western blot applications. By binding to sequestosome-1, this antibody enables accurate detection and analysis of the protein in various cell types.Sequestosome-1 is a multifunctional protein involved in various cellular processes, including selective autophagy, signal transduction, and inflammation. Dysregulation of sequestosome-1 has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic conditions.
Therefore, studying the expression and function of sequestosome-1 is crucial for understanding its role in disease pathogenesis and developing potential therapeutic strategies.With its high specificity and sensitivity, the Sequestosome-1 Polyclonal Antibody (CAB7758) is a valuable tool for researchers investigating the biological functions of sequestosome-1 in health and disease. Its applications in immunology, cancer research, and cell biology make it an essential reagent for studies aiming to unravel the complex roles of sequestosome-1 in cellular homeostasis and disease progression.
Product Name:
SQSTM1/p62 Rabbit Polyclonal Antibody
SKU:
CAB7758
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-440 of human SQSTM1/p62 (NP_003891.1).
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
Purification Method:
Affinity purification
Gene ID:
8878
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using SQSTM1/p62 Rabbit pAb (CAB7758) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
