The Sequestosome-1 Polyclonal Antibody (CAB11483) is a crucial tool for researchers studying Sequestosome-1, a protein linked to autophagy and intracellular protein degradation. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the Sequestosome-1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential asset for studies in cell biology and neurodegenerative diseases.Sequestosome-1, also known as p62/SQSTM1, is a multifunctional protein involved in various cellular processes, including selective autophagy and signaling pathways related to inflammation and oxidative stress. Its role in protein degradation and quality control makes it a key player in maintaining cellular homeostasis and preventing the accumulation of damaged proteins.
Research on Sequestosome-1 has implications for understanding diseases such as neurodegenerative disorders, cancer, and metabolic conditions where autophagy dysregulation is implicated.By using the Sequestosome-1 Polyclonal Antibody, researchers can gain valuable insights into the cellular functions of Sequestosome-1 and its potential as a therapeutic target for conditions associated with protein aggregation and cellular stress. This antibody serves as a reliable tool for investigating the complex mechanisms involving Sequestosome-1 and its impact on cellular health and disease progression.
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
Purification Method:
Affinity purification
Gene ID:
8878
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using SQSTM1/p62 Rabbit pAb (CAB11483) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
