The SEPT8 Polyclonal Antibody (CAB15011) is a valuable tool for researchers studying SEPT8, a protein known for its role in cell division and cytoskeletal organization. This antibody, generated in rabbits, is highly specific to human samples and is validated for Western blot applications. By binding to the SEPT8 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for research in cell biology and cancer.SEPT8 is a member of the septin family of GTP-binding proteins, which are involved in a variety of cellular processes, including cytokinesis, cell polarity, and vesicle trafficking.
Dysregulation of SEPT8 has been linked to diseases such as cancer, neurodegenerative disorders, and developmental abnormalities. Understanding the function of SEPT8 is crucial for unraveling its role in these conditions and potentially identifying new therapeutic targets.By utilizing the SEPT8 Polyclonal Antibody in your research, you can gain valuable insights into the function and regulation of SEPT8, ultimately contributing to advancements in the field of cell biology and potential therapeutic interventions for related diseases.
Product Name:
Septin 8 Rabbit Polyclonal Antibody
SKU:
CAB15011
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 348-427 of human Septin 8 (NP_001287728.1).
Sequence:
NKVK ETEL ELKE KERE LHEK FEHL KRVH QEEK RKVE EKRR ELEE ETNA FNRR KAAV EALQ SQAL HATS QQPL RKDK DKKN
This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
23176
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Septin 8 Rabbit pAb (CAB15011) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
