The SEPT7 Polyclonal Antibody (CAB3781) is a valuable tool for researchers studying SEPT7, a member of the septin family of GTP-binding proteins involved in cytokinesis and cell division. This antibody, generated in rabbits, has high specificity for human samples and has been validated for use in Western blotting applications.SEPT7 plays a critical role in cell division and is essential for maintaining the structural integrity of the cell during the process. Dysregulation of SEPT7 has been implicated in various diseases, including cancer and neurodegenerative disorders, making it a promising target for further research.
By specifically binding to the SEPT7 protein, this antibody enables researchers to detect and analyze SEPT7 levels in different cell types, providing valuable insights into its function and potential therapeutic applications. Whether studying cell division, cytoskeletal organization, or disease mechanisms, the SEPT7 Polyclonal Antibody is a reliable tool for advancing research in molecular biology and cell biology fields.
Product Name:
Septin 7 Rabbit Polyclonal Antibody
SKU:
CAB3781
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 307-436 of human Septin 7 (NP_001011553.2).
This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.
Purification Method:
Affinity purification
Gene ID:
989
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Septin 7 Rabbit pAb (CAB3781).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
