The SEPT5 Polyclonal Antibody (CAB12953) is a powerful tool for researchers studying SEPT5, a member of the septin family of GTP-binding proteins that play important roles in cytokinesis and cell division. This antibody, produced in rabbits, is highly specific to SEPT5 in human samples and is validated for use in applications such as Western blot and immunofluorescence.SEPT5 is known to interact with other septins and cytoskeletal proteins to form higher-order structures that are essential for cell division and cellular organization. Dysregulation of SEPT5 has been implicated in various diseases, including cancer and neurological disorders.
By using the SEPT5 Polyclonal Antibody, researchers can explore the function and localization of SEPT5 in different cell types, aiding in the understanding of its role in cellular processes and disease pathogenesis.The SEPT5 Polyclonal Antibody is a valuable tool for researchers interested in studying the molecular mechanisms of cell division, cytoskeletal organization, and disease pathology. Its high specificity and sensitivity make it an ideal choice for immunological and biochemical studies aiming to unravel the complexities of SEPT5 function in health and disease.
Product Name:
Septin 5 Rabbit Polyclonal Antibody
SKU:
CAB12953
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-369 of human Septin 5 (NP_002679.2).
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.
Purification Method:
Affinity purification
Gene ID:
5413
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Septin 5 Rabbit pAb (CAB12953) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
