Septin 5 Rabbit Polyclonal Antibody (CAB12953)
- SKU:
- CAB12953
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | Septin 5 Rabbit Polyclonal Antibody |
SKU: | CAB12953 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-369 of human Septin 5 (NP_002679.2). |
Sequence: | MSTG LRYK SKLA TPED KQDI DKQY VGFA TLPN QVHR KSVK KGFD FTLM VAGE SGLG KSTL VHSL FLTD LYKD RKLL SAEE RISQ TVEI LKHT VDIE EKGV KLKL TIVD TPGF GDAV NNTE CWKP ITDY VDQQ FEQY FRDE SGLN RKNI QDNR VHCC LYFI SPFG HGLR PVDV GFMK ALHE KVNI VPLI AKAD CLVP SEIR KLKE RIRE EIDK FGIH VYQF PECD SDED EDFK QQDR ELKE SAPF AVIG SNTV VEAK GQRV RGRL YPWG IVEV ENQA HCDF VKLR NMLI RTHM HDLK DVTC DVHY ENYR AHCI QQMT SKLT QDSR MESP IPIL PLPT PDAE TEKL IRMK DEEL RRMQ EMLQ RMKQ QMQD Q |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IHC-P,1:100 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | H5; SEPT5; CDCREL; PNUTL1; CDCREL1; CDCREL-1; HCDCREL-1; Septin 5 |
Positive Sample: | Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, cytoskeleton. |
Calculated MW: | 43kDa |
Observed MW: | 43kDa |
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.
Purification Method: | Affinity purification |
Gene ID: | 5413 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |