The SEPT1 Polyclonal Antibody (CAB17471) is a valuable tool for researchers studying SEPT1, a member of the septin family of GTP-binding proteins involved in various cellular processes such as cytokinesis and membrane dynamics. This rabbit-derived antibody is highly specific for human samples and has been validated for use in Western blot applications. By binding to the SEPT1 protein, this antibody enables precise detection and analysis in a wide range of cell types, making it ideal for studies in cell biology, cell cycle regulation, and cytoskeletal dynamics.
SEPT1 is known to play a critical role in cytokinesis, where it is involved in the organization of the contractile ring during cell division. Dysregulation of SEPT1 expression has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting its importance in cellular function and disease pathology. By studying the role of SEPT1 using this antibody, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.
Product Name:
Septin 1 Rabbit Polyclonal Antibody
SKU:
CAB17471
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 270-370 of human Septin 1 (NP_443070.5).
This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
1731
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Septin 1 Rabbit pAb (CAB17471) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
