The SENP7 Polyclonal Antibody (PACO17073) is a valuable tool for researchers studying SENP7, a protein involved in post-translational modification and regulating cellular processes. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By targeting the SENP7 protein, this antibody allows for precise detection and analysis in various cell types, making it an essential component for studies in molecular biology and cell signaling research.SENP7, also known as SUMO-specific protease 7, plays a crucial role in the SUMOylation process, controlling the attachment of SUMO proteins to target proteins and influencing their function.
This protein is implicated in multiple cellular pathways, including DNA damage repair, transcriptional regulation, and protein degradation, making it a key player in maintaining cellular homeostasis. Understanding the function of SENP7 is essential for unraveling its contribution to diseases like cancer, neurodegenerative disorders, and metabolic diseases, offering potential insights for therapeutic intervention in these conditions.
Antibody Name:
SENP7 Antibody (PACO17073)
Antibody SKU:
PACO17073
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human SENP7
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 6%SDS-PAGE,Lysate: 40 μg,Lane 1-2: A172 cells, 231 cells,Primary antibody: PACO17073(SENP7 Antibody) at dilution 1/800 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds.
Background:
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction.
Synonyms:
SUMO1/sentrin specific peptidase 7
UniProt Protein Function:
Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.
NCBI Summary:
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
